The HCP is a consortium including the Referral Centre for Developmental Anomalies and malformation syndromes of the Genetic Department and the Referral Centre for Intellectual Disability of the Child Neurology Department of the Femme-Mère-Enfant hospital in Lyon, which is part of the 2nd largest University Hospital in France (Hospices Civils de Lyon).
The Genetic and Child Neurology departments include:
- Clinical units providing a fine phenotypic characterization in dysmorphology, neurology, neuropsychology, neurophysiology, psychiatry and pediatrics
- Laboratory units including a cytogenetic lab with an array-CGH platform and a molecular genetics laboratory with non-invasive prenatal diagnosis and a next-generation sequencing/bioinformatics platform. In 2017, according to the national plan “France Médécine Génomique 2025”, the genomic platform AURAGEN has been set up in Lyon, providing whole genome analysis in a routine diagnostic setting (https://www.chu-lyon.fr/en/auragen-genome-sequencing-platform-very-high-speed).
The HCP team is particularly involved in developing personalized diagnosis, management and therapies in the field of developmental diseases as well as teaching activities, with a large spectrum of training courses, with a special interest on ethical issues.
The Genetic department includes a research team focusing on neurodevelopmental disorders (Genetics of Neurodevelopment team/GENDEV, Lyon Neuroscience Research Centre/CRNL, INSERM U1028, CNRS UMR 5292 University Lyon1). The Child Neurology department is affiliated to a research team focusing on cognition (L2C2, Institute of Cognitive Sciences, CNRS UMR 5304 University Lyon1).
At a regional and national level:
- The Lyon CLAD coordinates the inter-regional multi-site SUD-EST PACA referral Centre for developmental abnormalities, including the genetic departments of Grenoble, Saint-Etienne, Clermont-Ferrand, Marseille, Nice and Toulon. Moreover, it contributes actively to the National healthcare network AnDDI-Rares (andi-rares.org) concerning patients showing MCA with or without ID.
- The CRDI coordinates the National healthcare network DéfiScience (https://www.defiscience.fr) concerning rare diseases characterized by brain development abnormalities and/or intellectual disability.