ERN-ITHACA – Manchester Centre

Lead:  Prof Jill Clayton-Smith

Manchester Centre for Genomic Medicine

6th Floor St Mary’s Hospital

Oxford Rd

Manchester, M13 9WL

United Kingdom


Telephone: +44 (0)161 276 6506

Fax: +44 (0)161 276 6145



Manchester Centre for Genomic Medicine (MCGM) combines NHS services and The University of Manchester research and teaching, creating one of the leading centres for clinical genomics in Europe. MCGM is made up of NHS doctors, genetic counsellors, bioinformaticians, scientists and university research experts working in a purpose-built space – designed to promote interaction and creativity. The centre sees 10,000 new patients each year.

We work with genomic scientists worldwide and are proud to have translated many of our research discoveries into new diagnostic tests and treatment trials, to improve outcomes for our patients. We have trained genetic counsellors and scientists through internationally regarded academic and professional courses and workshops. Our informatic scientists have developed and promoted global networks for sharing clinical genomic data, and we are proud to host major international networks, to help provide quality-assured genomic services.

Our focus is to make personalised medicine a reality for patients and families; using next generation genomic technologies to give a precise diagnosis, understand risks and make the best treatment and management decisions.

Our practice is patient-centred, with expert genetic counsellors helping people understand and adjust to living with a genetic condition, and our systems are designed to ensure that each generation can be made aware about the risks of an inherited disease in their family.

Service to patients

Clinical Genetic Service and the Willink Biochemical Genetics Unit provide general clinics for populations around Manchester (including Lancashire and parts of Cheshire and Cumbria), and our metabolic services extend from across the North of England to Dublin.

Organization of the ERN ITHACA Manchester Centre

MCGM hosts national specialised services for lysosomal storage disease and neurofibromatosis types 1 and 2. Regional genetic services include paediatric metabolic conditions, prenatal assessment, dysmorphology, neuromuscular, neuropsychiatric, ophthalmic, cardiac and cancer genetics.

The Genomic Diagnostic Laboratory draws on the experience of 140 healthcare scientists and the fully accredited laboratory includes constitutional, oncology and biochemical genetics sections – integrated with research, the bioinformatics team and clinical services.

Our structure is designed to exploit the new generation of technologies, offering improvements in our ability to:

  • Scan the genome for disease causing changes
  • Monitor the progress of genetic conditions
  • Choose therapies and measure their impact.

We have translated research findings into new and validated genomic services. The new services complement a comprehensive base of diagnostics for a wide range of genetic disorders and molecular pathology indications. Our services attract referrals locally, nationally and internationally, principally from the NHS, but increasingly from research and clinical trials units and bio-industry.