{"id":425,"date":"2022-02-08T20:34:01","date_gmt":"2022-02-08T19:34:01","guid":{"rendered":"https:\/\/ern-ithaca.eu\/?post_type=expert-centers&#038;p=425"},"modified":"2024-11-12T14:08:46","modified_gmt":"2024-11-12T13:08:46","slug":"ern-ithaca-fondazione-irccs-istituto-neurologico-carlo-besta-di-milano","status":"publish","type":"expert-centers","link":"https:\/\/ern-ithaca.eu\/de\/about-us\/expert-centers\/ern-ithaca-fondazione-irccs-istituto-neurologico-carlo-besta-di-milano\/","title":{"rendered":"ERN-ITHACA \u2013 Mail\u00e4nder Zentrum (Carlo Besta)"},"content":{"rendered":"<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"368\" src=\"https:\/\/ern-ithaca.eu\/wp-content\/uploads\/2022\/03\/FONDAZIONE-IRCCS.jpg\" alt=\"\" class=\"wp-image-1550\" srcset=\"https:\/\/ern-ithaca.eu\/wp-content\/uploads\/2022\/03\/FONDAZIONE-IRCCS.jpg 1024w, https:\/\/ern-ithaca.eu\/wp-content\/uploads\/2022\/03\/FONDAZIONE-IRCCS-600x216.jpg 600w, https:\/\/ern-ithaca.eu\/wp-content\/uploads\/2022\/03\/FONDAZIONE-IRCCS-768x276.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Department of Pediatric Neuroscience<br><strong>Fondazione IRCCS Istituto Neurologico Carlo Besta<\/strong><br>Via Celoria, 11 \u2013 20133 Milan <br>ITALIEN<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/www.istituto-besta.it\/\">Website<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"lead\">Blei<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:15%\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/ern-ithaca.eu\/wp-content\/uploads\/2022\/03\/darrigo-foto.jpg\" alt=\"\" class=\"wp-image-1549\" width=\"144\" height=\"134\" srcset=\"https:\/\/ern-ithaca.eu\/wp-content\/uploads\/2022\/03\/darrigo-foto.jpg 947w, https:\/\/ern-ithaca.eu\/wp-content\/uploads\/2022\/03\/darrigo-foto-600x561.jpg 600w, https:\/\/ern-ithaca.eu\/wp-content\/uploads\/2022\/03\/darrigo-foto-768x718.jpg 768w\" sizes=\"auto, (max-width: 144px) 100vw, 144px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:85%\">\n<p class=\"wp-block-paragraph\"><strong>Dr. Stefano D\u2019Arrigo<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tel.<\/strong>: +39 02 2394 2210<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fax<\/strong>: +39 02 2394 81<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>email<\/strong>: stefano.darrigo@istituto-besta.it21<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"scope\">Geltungsbereich<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The area of expertise of the Unit, as member of the ITHACA European Reference Network (ERN), covers all syndromes exhibiting developmental anomalies and\/or intellectual disability (ID). About 1\/40 newborn has a congenital malformation (261\/10000 fetuses and newborn following EuroCAt reports), and 1\/40 has ID. Therefore, 3 to 5% of all human births show or will develop a developmental anomaly, among which at least 25-50% are of genetic or genomic origin. This huge population represents in reality the juxtaposition of a very large number of individually rare disorders showing an extreme diversity of causes and phenotypes. The jurisdiction and scope of expertise of the Istituto Neurologico Carlo Besta includes:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>over 5500 dysmorphic and multiple congenital anomalies syndromes (listed in the London Dysmorphology Database), among which over 3000 monogenic diseases, all chromosome abnormalities (most of them only detectable through array technologies), multifactorial, sporadic dysmorphological anomalies and embryofetopathies of environmental origin<\/li><li>&gt;1.500 monogene und Hunderte chromosomale Formen der geistigen Behinderung mit oder ohne begleitende Autismus-Spektrum-St\u00f6rung (ASD).<\/li><\/ul>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"service-to-patients\">Dienst am Patienten<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The population of metropolitan region of Milan covered by the Institute counts about 3 million inhabitants, but it attracts Italian citizens from all across the Country.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Center provides clinical diagnosis, genetic counseling and testing, neuropsychological evaluations and follow-up of the patients. The Institute is a 3<sup>rd<\/sup> level hospital for neurological diseases, therefore it offers high standards of care in its field, as well as advanced technologies and high level specialists for instrumental diagnostics (brain MRI and CT scan, EEGs and neurophysiology) and laboratory testing (metabolic and neurometabolic studies, advanced cytogenetics, NGS technology).<\/p>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"organization-of-the-center\">Organisation des Zentrums<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The Fondazione IRCCS Istituto Neurologico Carlo Besta counts 6 Managerial Departments, also organized in 8 Functional Departments based on the main fields of care and study. The Unit is part of the Managerial Department of Pediatric Neuroscience and of the Functional Department of Neurodegenerative and Rare Diseases. The Carlo Besta Neurological Institute is a University Teaching Hospital, home to several residents from different medical and surgical specializations; the ITHACA ERN Unit specifically welcomes trainees from the Child Neuropsychiatry, Medical Genetics, and Pediatrics residency programs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The staff of the Unit dedicated to the diseases and disorders related to the ITHACA ERN is composed by:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8211; Dr. Stefano D\u2019Arrigo (Child Neurologist) \u2013 Lead of the ITHACA ERN for the Center<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a><\/a> &#8211; Dr. Chiara Pantaleoni (Child Neurologist) \u2013 Sub Representative of the ITHACA ERN for the Center, Head of the team<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8211; Dr. Claudia Ciaccio (Clinical Geneticist)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&#8211; Dr. Sara Bulgheroni (Neuropsychologist)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Unit collects patients affected from a large variety of neurodevelopmental disturbs, complex disabilities, and syndromic phenotypes with neurological involvement.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Five are the main areas of expertise:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1. Developmental Delay (DD) and Intellectual Disability (ID), both simple than associated with other developmental and\/or malformative issue (see area 3);<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. Autism Spectrum Disorder, with or without cognitive impairment. This include specific research programs aimed to unravel the genetic basis of autism, improve the neuropsychological and etiological diagnosis and understand the possible role of phenotype modifiers (e.g. with microbiome analysis);<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3. Genetic Syndromes with developmental disorders and\/or neurological involvement. This area includes relatively common disorders (e.g. Fragile X Syndrome, chromosomal rearrangements) and ultra-rare disorders. Several research programs are active in such area, predominantly addressing Angelman and Angelman-like Syndromes and Smith-Magenis\/Potocki-Lupski Syndromes;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4. Pediatric Ataxias, congenital-malformative diseases and, in lesser extent, neurodegenerative ataxias. Research programs in this area include studies on Joubert Syndrome and investigations on the peculiar neuronal circuits of such conditions (Virtual Brain Project);<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">5. Cerebral Malformations, covering megalencephaly syndromes, cerebellar malformations, pontocerebellar hypoplasias, tubulinopathies, corpus callosum anomalies and other miscellaneous or mixed abnormalities.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The high standard of care is guaranteed thanks to the constant multidisciplinary approach of the Center. Beyond the professional figures member of the staff, periodic meetings on neuroradiology, neurosurgery, neurogenetics, epilepsy, and neuroncology are carried out, in order to assure the implemented care of the patients.<\/p>","protected":false},"featured_media":0,"template":"","tags":[],"country":[59],"center-status":[15],"class_list":["post-425","expert-centers","type-expert-centers","status-publish","hentry","country-italy","center-status-full-member"],"acf":{"name-city":"Fondazione IRCCS Istituto Neurologico Carlo Besta di Milano","representative":"Dr Stefano D'Arrigo","latitude":"45.420727","longitude":"9.212388","keywords-search":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ERN-ITHACA \u2013 Milan Center (Carlo Besta) - ERN ITHACA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ern-ithaca.eu\/de\/about-us\/expert-centers\/ern-ithaca-fondazione-irccs-istituto-neurologico-carlo-besta-di-milano\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ERN-ITHACA \u2013 Milan Center (Carlo Besta) - ERN ITHACA\" \/>\n<meta property=\"og:description\" content=\"Department of Pediatric NeuroscienceFondazione IRCCS Istituto Neurologico Carlo BestaVia Celoria, 11 \u2013 20133 Milan ITALY Lead Dr. Stefano D\u2019Arrigo Tel: +39 02 2394 2210 Fax: +39 02 2394 81 email: stefano.darrigo@istituto-besta.it21 Scope The area of expertise of the Unit, as member of the ITHACA European Reference Network (ERN), covers all syndromes exhibiting developmental anomalies and\/or [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ern-ithaca.eu\/de\/about-us\/expert-centers\/ern-ithaca-fondazione-irccs-istituto-neurologico-carlo-besta-di-milano\/\" \/>\n<meta property=\"og:site_name\" content=\"ERN ITHACA\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-12T13:08:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ern-ithaca.eu\/wp-content\/uploads\/2022\/03\/FONDAZIONE-IRCCS.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"368\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ERNIthaca\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"4\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ern-ithaca.eu\\\/about-us\\\/expert-centers\\\/ern-ithaca-fondazione-irccs-istituto-neurologico-carlo-besta-di-milano\\\/\",\"url\":\"https:\\\/\\\/ern-ithaca.eu\\\/about-us\\\/expert-centers\\\/ern-ithaca-fondazione-irccs-istituto-neurologico-carlo-besta-di-milano\\\/\",\"name\":\"ERN-ITHACA \u2013 Milan Center (Carlo Besta) - 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