{"id":368,"date":"2022-02-08T11:30:22","date_gmt":"2022-02-08T10:30:22","guid":{"rendered":"https:\/\/ern-ithaca.eu\/?post_type=expert-centers&p=368"},"modified":"2025-06-11T13:55:55","modified_gmt":"2025-06-11T11:55:55","slug":"ern-ithaca-zagreb-center","status":"publish","type":"expert-centers","link":"https:\/\/ern-ithaca.eu\/fr\/about-us\/expert-centers\/ern-ithaca-zagreb-center\/","title":{"rendered":"ERN-ITHACA \u2013 Zagreb Center"},"content":{"rendered":"
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Children’s Hospital Zagreb<\/strong>
Ul. Vjekoslava Klai\u0107a 16
10000, Zagreb
CROATIA<\/p>\n\n\n\n

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Site web<\/a><\/div>\n<\/div>\n\n\n\n
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Plomb<\/h2>\n\n\n\n
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Asst. Prof. Dr. Iva Hojsak<\/strong><\/p>\n\n\n\n

Phone: +385 (1) 4600 100<\/p>\n\n\n\n

Fax: +385(1) 4826 053<\/p>\n\n\n\n

e-mail : kdb@kdb.hr<\/a><\/p>\n<\/div>\n\n\n\n

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Dr. Ljubica Odak<\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n

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Champ d'application<\/h2>\n\n\n\n

En tant que membre du R\u00e9seau europ\u00e9en de r\u00e9f\u00e9rence (ERN) ITHACA, notre centre est sp\u00e9cialis\u00e9 dans tous les syndromes se caract\u00e9risant par des anomalies du d\u00e9veloppement et\/ou une d\u00e9ficience intellectuelle (DI). Environ 1 nouveau-n\u00e9 sur 40 pr\u00e9sente une malformation cong\u00e9nitale (261 pour 10 000 f\u0153tus et nouveau-n\u00e9s selon les rapports EuroCAt), et 1 sur 40 est atteint de d\u00e9ficience intellectuelle. Par cons\u00e9quent, 3 \u00e0 5 % de toutes les naissances humaines pr\u00e9sentent ou d\u00e9velopperont une anomalie du d\u00e9veloppement, parmi lesquelles au moins 25 \u00e0 50 % sont d\u2019origine g\u00e9n\u00e9tique ou g\u00e9nomique. Cette population consid\u00e9rable repr\u00e9sente en r\u00e9alit\u00e9 la juxtaposition d\u2019un tr\u00e8s grand nombre de troubles individuellement rares pr\u00e9sentant une extr\u00eame diversit\u00e9 de causes et de ph\u00e9notypes. Le champ d\u2019action et le p\u00e9rim\u00e8tre d\u2019expertise de ce centre ITHACA comprennent :<\/p>\n\n\n\n

    \n
  • plus de 5 500 syndromes dysmorphiques et anomalies cong\u00e9nitales multiples (MCA), parmi lesquels plus de 3 000 maladies monog\u00e9niques, toutes les anomalies chromosomiques (dont la plupart ne sont d\u00e9tectables qu\u2019\u00e0 l\u2019aide de technologies de puces \u00e0 ADN), les anomalies dysmorphologiques multifactorielles et sporadiques, ainsi que les embryof\u00e9topathies d\u2019origine environnementale<\/li>\n\n\n\n
  • >3 000 formes monog\u00e9niques et plusieurs centaines de formes chromosomiques de d\u00e9ficience intellectuelle, associ\u00e9es ou non \u00e0 un trouble du spectre autistique (TSA)<\/li>\n<\/ul>\n\n\n\n
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    Service aux patients<\/h2>\n\n\n\n

    The Zagreb Children\u2019s Hospital (Klinika za dje\u010dje bolesti Zagreb – KDB) provides comprehensive surgical and pediatric clinical and outpatient follow-up care for all patients with congenital anomalies except heart defects, from birth to adulthood. The postoperative care is maintained through the intensive care unit and ambulatory follow-up.<\/p>\n\n\n\n

    The Department of Medical Genetics and Reproductive Health offers clinical evaluation, genetic testing, and genetic counselling for various genetic disorders for patients of all age groups. The routine evaluation encompasses clinical examination by pediatrician\/medical geneticist, family history data, anthropometry (weight, length, and head circumference), family tree analysis, ENT and ophthalmologic evaluation, evaluation by pediatric neurologist, psychiatrist, speech and occupational therapists and other specialists depending on clinical features. The KDB also provides speech and occupational therapy, eating disorders treatment, and physical therapy. The Laboratory of Medical Genetics performs methods of classical cytogenetics, molecular karyotyping (MLPA – Multiplex Ligation-dependent Probe Amplification, MS-MLPA, and chromosomal microarray), genome analysis\/clinical exome sequencing\/hearing loss and deafness panel gene testing, genetic syndromes, and targeted gene testing for monogenic diseases: Duchenne-Becker muscular dystrophy, Rett syndrome, achondroplasia\/hypochondroplasia, fragile X syndrome, neurodevelopmental disorders, connective tissue diseases, genodermatoses, cardiac and kidney diseases, congenital eye\/hearing disorder.  Annually, genetic testing is available for 2300 patients while comprehensive clinical diagnostic evaluation is provided to 1700 patients with congenital anomalies, autism\/intellectual disability.<\/p>\n\n\n\n

    As part of the EUROCAT network (European network of population-based registries), there is an epidemiological monitoring of congenital anomalies in five Croatian regions, covering approximately 18% of Croatian population.<\/p>\n\n\n\n

    <\/div>\n\n\n\n

    Organisation du centre<\/h2>\n\n\n\n

    The KDB is the largest and the most comprehensive pediatric hospital in Croatia. Guided by the principles of integrated pediatric medicine, in collaboration with associated and academic institutions, and in accordance with the International Convention on the Rights of the Children (UNCRC), the Zagreb Children\u2019s Hospital (KDB) provides hospital medical care for \u2248 7000 children per year. Annually, around 25 000 children undergo outpatient follow-up\/ care.<\/p>\n\n\n\n

    The KDB meets the healthcare needs of children covering the entire territory of the Republic of Croatia (total population around 4 million people), as well as neighboring countries. The treatment of patients is carried out in the form of inpatient care with accommodation capacity of 75 beds at the Department of Pediatrics and through the Polyclinic Healthcare specialist outpatient consultation. As an integrative part of the Pediatric Clinic there is a Polyclinic for Children and Adolescent Psychiatry that provides diagnostics and management of neurodevelopmental disorders as well as various psychiatric disorders manifesting during childhood.<\/p>\n\n\n\n

    The KDB’s Pediatric Surgery Clinic is the largest pediatric surgery facility in the Republic of Croatia (83 beds) and provides routine surgical procedures but also surgery of more complex, rare congenital anomalies, except cardiac defects. The intensive care unit provides postoperative care of the most severe pediatric and surgical patients. As part of the integrative healthcare, there is also radiology diagnostics encompassing ultrasound, X-ray, magnetic resonance, and computed tomography. Laboratory diagnostics is enabled for various type of hematological, biochemistry and microbiology testing.<\/p>\n\n\n\n

    Based on the long-term experience and quality of healthcare, the KDB is the base for three referral centers of the Ministry of Health of the Republic of Croatia and education center for students and residents. In collaboration with domestic and international academic institutions, the KDB participates in scientific research projects. The results of these activities are presented at scientific and professional conferences and published in indexed journals (Medline, Currents Contents).<\/p>","protected":false},"featured_media":0,"template":"","tags":[],"country":[49],"center-status":[15],"class_list":["post-368","expert-centers","type-expert-centers","status-publish","hentry","country-croatia","center-status-full-member"],"acf":{"name-city":"Zagreb Center","representative":"Dr Mijana Kero ","latitude":"45.815011 ","longitude":"15.981919","keywords-search":""},"yoast_head":"\nERN-ITHACA \u2013 Zagreb Center - ERN ITHACA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ern-ithaca.eu\/fr\/about-us\/expert-centers\/ern-ithaca-zagreb-center\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ERN-ITHACA \u2013 Zagreb Center - ERN ITHACA\" \/>\n<meta property=\"og:description\" content=\"Children’s Hospital ZagrebUl. 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