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Gene/disorder under study

NPAS3 [MIM*609430]

Abstract

The NPAS3 gene has been suggested to be involved in neurodevelopmental disorders (PMID: 33758288). We wish to confirm its role and better define the associated phenotypic spectrum.

To gather clinical and molecular data from patients with de novo variants in NPAS3, with a particular focus on developmental trajectories.

If you are following a patient who meets these criteria and would like to take part in this collaborative study, please contact us.

Coordinating clinicians

Marion AUBERT MUCCA – aubertmucca.m@chu-toulouse.fr

Alban ZIEGLER – ziegler.a@chu-toulouse.fr

Institution

Medical Genetics Department, Toulouse Hospital, Toulouse, France

Specific requirements beyond clinical data and genotype data sharing:

1- Re-analysis of DNA samples: No

2- Resampling of patients: No

3- Linked to a translational/basic research project: No