ERN-ITHACA workplan is divided into 12 thematic Workgroups (WG). The three first WG are transversal groups dedicated to the network general coordination, while the remaining nine focus on specific scientific topics. In addition to these 10 WG are two Advisory Boards – one led by the Patient Council (PC), another one committed to Ethical, Legal and Social Issues (ELSI) – and one special taskforce, part of the Training & Education WG, dedicated to the APOGeE project.