The SysNDD database is based on its predecessor database, SysID ( It contains a manually curated catalogue of published genes implicated in neurodevelopmental disorders (NDDs) and classified into primary and candidate genes according to the degree of underlying evidence.

Furthermore, manually curated information on associated diseases and phenotypes is provided. To allow interoperability and mapping between gene-, phenotype- or disease-oriented databases, we center our approach around curated gene-inheritance-disease units, so called entities. SysNDD is updated every 3-4 months and can be utilized for a broad spectrum of tasks from both research and diagnostics.

One of our long-term goals is to incorporate the SysID/SysNDD data into other gene/disease-relationship databases like the Orphanet ontology.

SysNDD has been built and is maintained by Christiane Zweier (Head of the Department of Human Genetics at the University/ University Hospital Bern, Switzerland) and Bernt Popp (senior physician at the Institute for Clinical Genetics, University Hospital TU Dresden, Germany and scientist at the Institute of Human Genetics at the University Hospital Leipzig, Germany). CZ has been involved in establishing and updating SysID from its start in 2009. She is performing and coordinating curation and updates. BP developed and programmed the new SysNDD database and will be integrating further functionality including associated variants and network analyses in future updates.

SysNDD database website